Endophenotypes and suicide behaviour

Authors

  • L. Jimenez-Treviño Área de Psiquiatría Universidad de Oviedo Oviedo, España
  • H. Blasco-Fontecilla Departamento de Psiquiatría Fundación Jiménez Díaz (Madrid)
  • Braquehais Hospital Universitario Vall d’Hebron Barcelona
  • A. Ceverino-Dominguez Centro de Salud Mental de Hortaleza Madrid Spain
  • E. Baca-Garcia Departamento de Psiquiatría Fundación Jiménez Díaz (Madrid)

Keywords:

Candidates endophenotypes, suicide behaviour, personality traits, neuropsychology, neurochemistry, neuroimaging

Abstract

Background. Recent studies have suggested that genetic predisposition to suicidal behavior may be independent of the risk of suicide associated to mental disorders, such as affective disorders, schizophrenia or alcohol dependence.

Given the suicidal behavior heterogeneity and its hereditary complexity, the need to find demonstrable intermediate phenotypes that may make it possible to establish links between genes and suicide behaviors (endophenotypes) seems to be necessary. The main objective is to review which are the candidate endophenotypes of suicidal behaviors.

Methods. We carried out a non-systematic review of all published literature in English, French and Spanish in MEDLINE. The search terms were endophenotypes and suicide behaviors.

Conclusions. The main candidate endophenotypes of suicidal behaviors are neuropsychological (decision-making, executive functions), personality traits (impulsivity, aggressiveness, and neuroticism), neurochemistry (5-HIAA in CNS) and neuroimaging (fMRI of cerebral amygdala or PET of prefrontal cortex metabolism).

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Published

2011-01-01

How to Cite

L. Jimenez-Treviño, et al. “Endophenotypes and Suicide Behaviour”. Actas Españolas De Psiquiatría, vol. 39, no. 1, Jan. 2011, pp. 61-69, https://actaspsiquiatria.es/index.php/actas/article/view/727.

Issue

Vol. 39 No. 1 (2011)

Section

Review